Ke$ha revealed the main idea behind the video in an interview explaining that ' about and all hot vampire babe friends breaking into a hotel on another planet, and at the end we all turn into this beautiful stardust. It was directed by Paul Hunter and Dori Oskowitz. The first video for 'Take It Off' premiered on August 3, 2010.

For the Kesha and the Creepies: Fuck the World Tour and the Rainbow Tour, the song is a rock version again, this time at a faster tempo and the whole song is performed without any parts omitted. The first half of the second verse is omitted with the verse starting at 'Now now we're getting so smashed.' Then the second part of the chorus is also omitted for the next two times it is sung. For the Warrior Tour, the song is more rock orientated and has a more sex appeal to the song. The song has been rearranged a few times when performing it live. I was like, What does that even make me?'. She explained that the song came about when she was out one night and was visiting a transsexual bar, stating, 'I have a song called 'Take It Off' about when I went to a drag show, and how really turned on I was by these transvestite men taking clothes off. During an interview with Esquire magazine Ke$ha was asked about her song writing process and used 'Take It Off' as an example of how her songs come to fruition. The song was produced by Luke with vocal editing done by Emily Wright. It was recorded at Conway Recording Studios in Los Angeles, California, and at Dr. 'Take It Off' was written by Ke$ha, alongside Dr.

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